Description
This dataset contains anonymised whole slide images (WSIs) of human liver received during routine clinical practice, comprising a variety of benign and malignant diagnoses. This dataset includes biopsies and surgical resection specimens, from both native and transplant liver specimens along with any associated specimens (e.g. gallbladder). It includes a mixture of non-targeted/medical and tumour (primary or metastatic) specimens and gallbladder specimens. All cases include a H&E stain along with any additional histochemical or immunohistochemical stains where available.
Dataset Overview
| Title | NPIC Liver 6 |
|---|---|
| Short name | NPIC Liver 6 |
| Age at extraction |
P20Y P75Y |
| Anatomical site |
gallbladder liver pancreas bile duct peritoneum vein liver hilum lymph node |
| Animal species |
Homo sapiens |
| Specimen types |
Histopathology |
| Image type |
Brightfield |
| Extraction method |
Biopsy Resection Biopsy (tumour) Biopsy (transplant) Biopsy (non-tumour) Resection (explant) |
| Image resolution | |
| Type of access | Direct access |
| Staining |
Cytokeratin Associated Marker 5.2 P63 Immunohistochemical (IHC) staining for CD56 Ziehl-Neelsen stain (SP or TB infection) Immunohistochemical (IHC) staining for Ki-67 P53-DO7 Wade-Fite Prostate Specific Antigen Glypican-3 CytoKeratin 7 Alcian Blue (AB) - Periodic Acid-Schiff (PAS) - Hematoxylin (H) Estrogen Receptors CarcinoEmbryonic Antigen (Monoclonal) CarcinoEmbryonic Antigen Polyclonal Alpha-Synuclein Wilms tumor Hepatitis B surface antigen Shikata Orcein stain Discovered On GIST 1 Hepatitis B Core Antigen Martius Scarlet Blue Immunohistochemical (IHC) staining for CD20 GLUcose Transporter Immunohistochemical (IHC) staining for caudal-related homeobox gene 2 Periodic Acid-Schiff with Diastase Sudan IV Immunohistochemical (IHC) staining for CD31 P16 Antihuman Epithelial Antigen Hep Par1 Antibody C4d Cancer Antigen 125 Immunohistochemical (IHC) staining for CD34 Immunohistochemical (IHC) staining for CD68 Programmed Cell Death Ligand 1 Reticulin Gram Cytokeratin AE1/AE3 Melanoma A B-Catenin CytoKeratin 20 MNF116 CytoKeratin 5 and 6 Synaptophysin Immunohistochemical (IHC) staining for CD45 Periodic Acid-Schiff Human Melanoma Black 45 Immuno Spare Hematoxylin and Eosin CytoKeratin 5 Gross Cystic Disease Fluid Protein-15 Perls (Iron) Thyroid Transcription Factor-1 Progesterone Receptor A Prostatic Acid Phosphatase Elastic Van Gieson Immunohistochemical (IHC) staining for CD3 S100 protein Cancer Antigen 19-9 CytoKeratin 19 CytoKeratin 8 and 18 Hematoxylin and Eosin Frozen CytoMegaloVirus PAX-8 Rhodanine Grocott's Methenamine Silver Amylase Alpha Masson Fontana Chromogranin A Human Epidermal Growth Factor Receptor 2 Myeloperoxidase Glutamine Synthetase Alpha-FetoProtein Van Gieson Sudan IV Defat Congo Red |
| Cite as | |
| Keywords |
liver biopsies whole slide image |
| Year | 2026 |
| DOI | |
| Version | 1.0.0 |
| Number of WSIs | 3484 |
| Number of cases | 322 |
| Number of biological beings | 322 |
| Annotations | 0 |
| Size | 4944851629486 |
| Access approval process | Registered Access |
| Duration of use | Limited to the duration of the purpose of the data access request |
| Center name | National Pathology Imaging Co-operative (NPIC) |
| Metadata standard version | 2.0.0 |
Terms of use
| Allowed uses |
Research use |
|---|---|
| Allowed geographical distribution | Countries with GDPR adequacy |
| Geographical areas |
UK |
Policy & Terms of Use
DISCLAIMER: The use and sharing of Bigpicture data is dictated by the Bigpicture Data Sharing Agreement. The Policy Text comprises a concise overview thereof, however, only the official and formally signed contractual documents (i.e. the Data Sharing Agreement, the Data Processing Agreement, the Consortium Agreement, and the Grant Agreement) related to Bigpicture Data Sharing and Processing have a binding value. Summary of relevant clauses for Data Users This document serves as an overview of the relevant clauses and sections of clauses for Data Users, and is for reference purposes only. In case of doubt about the contents of the clauses, the original text of the DSA always takes precedence over this summary. The full text of the relevant clauses is also included in this document. Clause 2. [Definitions] ‘Data User’ means any Beneficiary whose Employees are exercising the Access Rights to certain Data in accordance with the terms set out in this Agreement and defined by the Data Contributor in the ToU. For the avoidance of doubt, Data Users may include employees of Affiliated Entities and Linked Third Parties, Sub-Contractors, to the extent that those entities enjoy the rights and obligations under this Agreement. In next phases of the Project, Data Users will also include Slide Contributing Third Parties and finally Third Parties. Clause 3. [Contribution of the Data] Data Contributors and Data Users shall sign the Hosting and Processing Agreement with Hosting Beneficiaries as set forth in EXHIBIT 4. Clause 5. Data Access Clause 5 outlines the terms and conditions for Data Access. Beneficiaries (as potential Data Users) can request access to specific datasets by following the Terms of Use set by the Data Contributor, in line with the Consortium Agreement and data protection laws. To apply, they must submit a request through the REMS portal, providing necessary details such as the dataset, data users, employees, and the research purpose. If the requesting party is in a non-European Economic Area country without an EU adequacy decision, a data transfer agreement must be signed to meet cross-border data transfer obligations, such as the Standard Contractual Clauses issued by the European Commission or comply with another compliant cross-border data transfer mechanism. A Transfer Impact Assessment may also be required. Clause 6. [Obligations of the Data Users] Clause 6 outlines the obligations of the Data Users. They must ensure that its Employees use the Data only for the agreed purpose, as specified in the Data Access request, and in compliance with the relevant agreements and legislation. The Data must not be processed in ways incompatible with its original purpose. The Data Contributor retains the right to use their Data for their own purposes if they are the Data Controller or have a legal right to do so. Each Data User processing Data must: - Comply with applicable Data Protection Legislation. - Act proportionately to the research aim when acting as a Controller. - Follow recognized ethical standards for scientific research. - Adhere to the conditions and restrictions set by the Data Contributor in the Terms of Use. Specific obligations for Data Users include: - Implement guidelines and procedures to ensure Employee compliance with the DSA, ToU, and Data Protection Legislation. - Ensure Employees treat all Data as confidential unless otherwise indicated and comply with data transfer rules for countries outside the EU/EEA. - Ensure authorised third parties process Data only according to instructions. - Access and process Data only as necessary for the Project or approved Research Use. - Notify the Data Contributor of any errors in the Data or security breaches without undue delay. - Accept that Data access may be interrupted or suspended for maintenance or security reasons. - Accept updates to Data and remove earlier versions if reissued due to Data Subject requests. - Implement security measures to protect Data downloaded from the Bigpicture Platform. - Delete Data upon a justified request from the Data Contributor. When accessing Personal Data: - For Research Use, the Data User will be considered a Controller unless stated otherwise in EXHIBIT 2 or agreed in writing between the concerned Data Contributor and Data User in a separate agreement. - For Implementation of Action, roles are outlined in EXHIBIT 2. Clause 10. [Data Protection Impact Assessment (DPIA)] Clause 10 outlines the obligations for Beneficiaries regarding the execution of a DPIA. Data Users must ensure they access Personal Data only if a DPIA is not required or if a DPIA has been completed and its conclusions permit the planned use. The Data Contributor or its Data Access Committee (DAC) can request the DPIA from the Data User before granting access to the data. Clause 11. [Non-transferability] Data Users (except where Data User is the Beneficiary which contributed the relevant Data) must ensure that neither they nor their Employees transfer or disclose the Data or any material to any third party, including other Employees, unless: a) Permitted under the DSA, b) A separate Data Access request has been filed and approved by the relevant Data Contributor, or c) Permitted under the provisions on the rights of the Affiliated Entities, Linked Third Parties and Sub-Contractors in the Consortium Agreement and the DSA. Clause 15. [Term and termination] Clause 15 outlines, insofar as relevant to the Data Users, the consequences of termination or expiration of the DSA. a) Upon termination or expiration of the DSA, all Beneficiaries must stop processing the relevant Data. However, if a Beneficiary started processing Data for research before termination, they can continue until completion, unless the termination is due to specific listed reasons or the withdrawal of necessary authorizations. b) Access Rights to the Data will be immediately revoked for Data Users and their Employees whose participation is terminated. c) All Data Users and their Employees must securely delete the Data they received via the Bigpicture Platform and remove any existing copies, unless permitted otherwise by the Data Contributor or applicable law. d) Data Users must confirm the Data erasure or provide reasons for retention if requested by the Data Contributor. EXHIBIT 4: Hosting and Processing Agreement Agreement to be signed between Data Contributors/Data Users and Hosting Beneficiaries, whereby the Data Contributors and Data Users act as (or on behalf of) Controllers and Hosting Beneficiaries (CSC and UU) act as Processors.